When should the annual renewal application for the DEA registration certificate be submitted?

The annual renewal application for the DEA registration certificate should be submitted 45 days before expiration to ensure there is no lapse in registration. This timeline allows for the necessary processing by the DEA, which can take some time. By submitting the application 45 days in advance, registrants can avoid potential issues that may arise from delays, such as being unable to legally handle controlled substances during the renewal process. This proactive approach helps maintain compliance with federal regulations and supports uninterrupted operations for practitioners who rely on DEA registration for their medical or pharmaceutical responsibilities.